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PubMed COVID-19 Clinical Care

1551 - 1560 of 5506 results found

COVID-19: A complex disease with a unique metabolic signature

Date
Thursday, November 09, 2023 - 4:00 AM
Description
Plasma of COVID-19 patients contains a strong metabolomic/lipoproteomic signature, revealed by the NMR analysis of a cohort of >500 patients sampled during various waves of COVID-19 infection, corresponding to the spread of different variants, and

Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Date
Wednesday, November 08, 2023 - 4:00 AM
Description
CONCLUSIONS: The emergence of E484A and E484Q prior to widespread population immunity may have been limited by fitness costs. In populations already exposed to the early immune escape epitope E484K, the Omicron founder background may have provided a